Will taking Tranylcypromine and Modafinil at the same time affect their efficacy?

Q. Can I take Tranylcypromine and Modafinil at the same time?

Answered by
Dr. Amrit Agarwal
and medically reviewed by Dr. Sushrutha Muralidharan
This is a premium question & answer published on Jan 07, 2022

Hi doctor,

A question related to the compatibility of two drug molecules, an anti-depressant and a molecule designed to help overcome sleep disorder, enhance wakefulness. Jatrosom (Tranylcypromine) 20 mg thrice per day, and additionally Modafinil 100 mg in the morning. The Jatrosom treatment leads to tiredness up to the point that early in the afternoon, rest is necessary (sleeping time up to two to three hours). Modafinil is supposed to overcome this tiredness. From a neuropharmacological point of view, the two molecules taken together in treatment may interact adversely. What is the best medical advice on the question raised? Kindly give your opinion.



Welcome to icliniq.com.

Jatrosom (Tranylcypromine) is a drug used to treat depression and may lead to drowsiness or tiredness as its side effects. On the other side, Modafinil is a psychostimulant drug. A combination of both might affect each other's efficacy or counteract each other's effect.

So I would suggest you the following:

1) Stop taking Modafinil or use half of its dose that is 50 mg. Slightly taper down, then stop it. Also, if you taper down or stop Modafinil simultaneously, taper down Jatrosom 20 mg to two times a day or a total of 50 mg (two and a half tablets) and 50 mg of Modafinil (half of the previous dose).

2) Instead of Modafinil, start taking tea or coffee (not an empty stomach) as natural neuro stimulants.

3) Also, do a physical workout for 40 minutes per day as it will balance the hormonal secretion, increases circulation also will release serotonin and endorphins, and might decrease your dose of Jatrosom.

4) Eat healthy and less oily food. This, too, will make you confident and disciplined.

5) Use a good aroma or perfumes to elevate your mood. It also increases the release of happy hormones.

6) Indulge yourself in learning something new. This will divert your mood and might bring a change in a monotonous life, which all of us complain about.

7) Be thankful to almighty or your near and dear ones for whatever good things are present in your life. Practice saying thanks to almighty or the people around you (if verbally not possible than in your thoughts or in mind) 35 to 40 times per day. This will bring to your notice the good things, and in a few days, you will feel good or better than earlier. I am not advising you to stop thinking negatively. I am advising you to start thinking positively.

8) You can consult your clinician for the same.

I hope this was helpful.

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