I am allergic to Celebrex and I have started experiencing the same side effects with Indomethacin and Misoprostol. Why?

Q. Do Indomethacin and Misoprostol contain the same ingredients as Celebrex?

Answered by
Dr. Amrit Agarwal
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on Aug 26, 2023

Hello doctor,

I am allergic to Celebrex, as it causes me hypertension and chest pains when I take it. After undergoing hip surgery recently, my doctor prescribed Indomethacin and Misoprostol as substitutes for Celebrex. However, I have started experiencing the same side effects with these two drugs as I did with Celebrex, including extreme anxiety, confusion, and hypertension. A pharmacist informed me that Indomethacin and Misoprostol are the same drugs found in Celebrex, suggesting that there may have been an error in prescribing them to me. I shared this information with my family doctor, but they did not believe that information to be true. Now, I am feeling afraid and uncertain. Should I continue taking the prescribed drugs as advised by my doctor or should I stop taking them? My question is, is Indomethacin and Misoprostol combination the same drugs as those found in Celebrex, as the pharmacist informed me?

Kindly suggest.



Welcome to icliniq.com.

I read your query and understood your concern. I would like to inform you that Celebrex (nonsteroidal anti-inflammatory drug) contains Celecoxib, whereas as you mentioned, you have been prescribed Indomethacin (nonsteroidal anti-inflammatory drug) and Misoprostol (pPostaglandin E1 analog) as a replacement. Therefore, there should be no doubt about their composition. Secondly, if you are experiencing the same side effects from Indomethacin and Misoprostol, I suggest you consult your doctor in person. They can determine whether these side effects are certainly caused by the medication or if there might be another underlying issue. I hope this has helped you. Kindly follow up if you have more doubts.

Thank you.

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