Q. Will removing half a pellet from Doxypal capsule affect its delayed-release mechanism?

Answered by
Dr. Arul
and medically reviewed by Dr. Vinodhini. J
This is a premium question & answer published on Feb 18, 2020

Hello doctor,

I have a question with respect to Doxypal DL medicine and my question is whether the delayed release remains active when I would open a capsule to remove half of the pellets. The capsules are 100 mg, and I would like to take 50 mg, but I need the delayed release to remain working because otherwise, I get too many side effects with nausea. The side effects are also the reason I would like to take 50 mg two times a day instead of 100 mg once a day. I investigate and found that the delayed-release mechanism can be in the capsule (and if this is the case, I cannot open it, to remove half of the pellets, because it will loose the delayed release mechanism). But I read on the internet that the delayed-release mechanism can also be in the pellets inside of the capsule. If this is the case, I could open it, and remove half of the pellets, and the delayed-release mechanism would still be working. I want to know is the delayed-release mechanism of Doxypal 100mg RL contained in the pellets or is it due to the capsules?



Welcome to

The delayed-release capsule contains the active drug (Doxycycline) and few other excipients that slowly release the active drug from it. So, the active drug is mixed with the excipients and put into the capsule. So, if you divide the capsule into equal half, it still works. Still, it is delayed-release and you can make 50 mg dosage.

You also see that whether the infection in acne is controlled with 50 mg dose. If so, you can follow it. If not controlled, then 100 mg must be taken. The benefit and side effects should be weighed to choose the balanced dosage.

Was this answer helpful?


Same symptoms doesn’t mean you have the same problem. Consult a doctor now!

Related Questions:
As I took the wrong dosage for H. pylori infection, bacteria are now resistant. Please help.

.. already have taken a very effective dose of capsule Pylera (Bismuth subcitrate potassium, Metronidazole, and Tetracycline hydrochloride). Every bug in another human responds differently. I suggest you test for the H.pylori stool antigen, confirm w...   Read full

What are the tiny black dots that came up after gallbladder surgery?

.. (attachment removed to protect patient identity) are a bit blurred and these are tiny small papules. Are they itchy? There are two to three possibilities. I will mention it one by one. First is drug reaction - As you had undergone surgery, you mu...   Read full

I am experiencing side effects of Doxycycline, which I took for UTI. Please help.

.. that you had a urine test, but there are different types of urine test like a dipstick, which is done at the office, a complete analysis, which is done in the laboratory and a urine culture. I am more interested in the last two. With all due respe...   Read full

Also Read Answers From:

Also Read

Benefits of Sudarshan Kriya Breathing Technique
Sudarshan Kriya is a type of breathing exercise that connects the mind with the body through breathing. Consult a specia...  Read more»
Health Benefits of Meditation
Anxiety, low self-esteem, and depression are the major problem these days. Meditation can be a solution to all these pro...  Read more»
Sporting Events During the Pandemic
If you are into any sporting event and plan a trip to an outdoor or indoor stadium, or you are an organizer or an athlet...  Read more»

Ask your health query to a Wellness Expert online?

Ask a Pharmacologist Now

* guaranteed answer within 4 hours.

Disclaimer: No content published on this website is intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician. Seek advice from your physician or other qualified healthcare providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website. Read our Editorial Process to know how we create content for health articles and queries.