Dr. Zulfiqar Ahmed
Diabetology
The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.
Answered by
Medically reviewed by
Patient's Query
Hi doctor,
I am currently receiving Prolia injections. I received my first shot six months ago and my second shot five days ago. My question is regarding PTH blood results. My PTH eight months ago was 76 pg/mL. Last month it was 169 pg/mL. I was wondering if the Prolia injection can cause it to elevate. Also, I was told by my former endocrinologist that I have FHH despite normal findings on the CaSR test and that it is an entirely benign entity that should cause me no concern. I have attached my laboratory test results for you to check. Please help.
Hi,
Welcome to icliniq.com.
I understand your concern.
Yes, Denosumab can increase parathyroid levels, especially if there is kidney impairment. That is also in the first few months of Denosumab treatment. May I know why you are taking Denosumab? When were you diagnosed with FHH (familial hypocalciuric hypercalcemia)? For how long have you been taking Denosumab? I will need a more detailed history for suggestions.
Revert with answers.
Warm regards.
Patient's Query
Hello doctor,
Thank you. I am taking Denosumab for osteoporosis or osteopenia to increase bone density after the Dexa scan showed a low score. I have never had a fracture. I was on Fosamax in the past, but it did not show any benefit. The doctor said there was no kidney impairment. I have only started Denosumab this year since the first shot every six months. I was told I had FHH in 2018. I am also taking vitamin D3 4000 IU daily and calcium carbonate 1200 mg daily. Please advise.
Hi,
Welcome back to icliniq.com.
I understand your concern.
If renal function is fine, the increase in parathyroid hormone may be temporary, and it may come down over a few months. You can recheck your parathyroid levels before taking the next dose of Denosumab. So, your next dose would be after six months, so then you can check levels. If it is coming down, you can go for your Denosumab. For FHH, usually parathyroid is mildly elevated or even in the high normal range, and it should not be that much high. Denosumab can also elevate vitamin D (1, 25 vitamin D) as well but it is temporary as well.
Hope this answers your query.
Kind regards.
Was this conversation helpful?
Same symptoms don't mean you have the same problem. Consult a doctor now!
Diabetology
Related Questions
What is the outcome of the tests taken for breast cancer?
Does my high calcium level need treatment?
Uses of Osteoclast Inhibitors In Early Breast Cancer - An Overview
Hyperparathyroidism - Types, Causes, Symptoms, and Treatment
Maternal Hypercalcemia Effect on the Neonate
Pseudohypoparathyroidism - Causes, Symptoms, Complications, Diagnosis, and Treatment
Disclaimer: No content published on this website is intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician. Seek advice from your physician or other qualified healthcare providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website. Read our Editorial Process to know how we create content for health articles and queries.
This website uses cookies to ensure you get the best experience on our website. iCliniq privacy policy
