Does a negative Ber-EP4 in cytology suggest metastasis?

Question

Hi doctor,

I had my cytology report from pelvic wash before hysterectomy. I need some clarifications on the pathology report. The report showed atypical cells - reactive mesothelial cells, enlarged and crowded nuclei, positive for calretinin and negative for Ber-EP4. Could these be metastatic breast cancer cells? I have a previous history of TNBC.

Answer 1

Hi,

Welcome to icliniq.com.

You have not mentioned the reason for which the hysterectomy was done. Before commenting, the location of the mass should be known. Usually, calretinin stain is applied to differentiate between mesothelioma and other metastatic carcinomas or adenocarcinomas. Calretinin can be positive in breast malignancy.

Certain ovarian tumors, adrenal cortical tumors, olfactory neuroblastoma, and so on, also give a positive calretinin reaction. So, mention where the tumor or mass is located, and accordingly, further comments can be given. And histopathology examination is advised for reaching the final diagnosis.

I hope this helps.

Take care.

Thank you.