I have serotonin syndrome. Will it damage my brain?

Question

Hello doctor,

I have serotonin syndrome or toxicity from a tricyclic antidepressant. I stopped taking it seven weeks ago. Most of my neurological symptoms have gone. I stick to a low tryptophan diet, but if I eat something higher in tryptophan or get stressed, I feel nauseous, depressed, agitated, and I cannot sleep. This happens every few days.

I cannot take supplements such as Vitamin D3. I am post menopausal and need calcium, but I cannot eat dairy or drink milk without severe effects. My question is, will my sensitivities pass in time and will my serotonin rebalance? I am so frightened that I have permanent endocrine or brain damage. Currently, I am taking a Propranolol mini pill.

Kindly help.

Thank you.

Answer 1

Hi,

Welcome to icliniq.com.

Since your serotonin syndrome is drug-induced, it must be normalized within a washout period. I mean normalized gradually once you stop it. You may take another antidepressant that is safe for you.

Eating tryptophan-rich foods or stress-inducing foods may cause some symptoms in you, I feel, which may not be related to serotonin syndrome. That looks like your depression related issues only. It needs better drugs. Please discuss with your clinician about current symptoms.

Your brain and endocrine systems are normal (attachment removed to protect patient identity). The only thing you must take is better antidepressants and psychological counselling. Vitamin D dosage needs to be adjusted if it is causing trouble. This may not be related to serotonin syndrome.

I hope this helps you.

Take care.