HomeHealth articlesovulationHow to Apply Progesterone Cream - Ovulation Process | Indications | Dosage |

How to Use Cream for Fertility

Verified dataVerified data
How to Use Cream for Fertility

4 min read


This article discusses the normal ovulation process, what are the available creams for improving fertility, and how it is to be used.

Medically reviewed by

iCliniq medical review team

Published At April 13, 2018
Reviewed AtAugust 26, 2022

How Does the Ovulation Process Occur?

When an ovum is released from any one of the ovaries, it comes inside the uterus (to become fertilized by the sperm). This phase is known as the luteal phase. At this time, the uterine lining becomes thick and with lots of blood vessels to provide protection and nutrition to the fertilized egg in preparation for a possible pregnancy. If fertilization does not occur, this uterine lining starts to shed off, and menstruation or period may commence.

For conceiving a baby, ovulation is the necessary process that is well regulated by the female hormones progesterone and estrogen. There are many signs and symptoms associated with the ovulation process. They are:

  • A slight increase in the temperature of the body.

  • White mucus secretion from the cervix or vagina.

  • Pain in the lower abdominal area.

  • A peak of sexual desire during this phase.

Some research shows that a woman may become more conscious of her looks and facial attractiveness during this time.

How to Know About Initiation of Ovulation?

There are many methods to calculate the ovulation time. The most reliable and easy way is to remember that ovulation starts approximately 14 days before the expected menstruation date.

What Is the Cream Available for Fertility?

Progesterone Creams: This is a hormonal cream mainly used for enhancing the process of fertility. Progesterone is a hormone that increases the basal temperature of the body. That is why it is also referred to as a warm temperature hormone. This hormone is mainly used for manufacturing creams that are used to improve fertility. It is used in those patients who have low progesterone levels.

The most important function of this hormone is developing the uterus for pregnancy. When pregnancy happens, secretion of progesterone occurs for eight weeks. When pregnancy does not occur, secretion will become low and cause menstruation.

Progesterone cream makes the uterus healthy so that the fertilized egg can attach and survive, makes the vagina and cervix more accessible for the sperm to enter, prevents the rejection of fertilized egg, promotes the development of the fetus, and increases sexual desire, which ultimately enhances the pregnancy.

What Are the Indications for Using Progesterone Cream?

There are quite a few indications for using progesterone cream for pregnancy. Some of them are:

  • A woman who has had multiple and recurrent miscarriages.

  • Absence of menstruation.

  • PCOS (polycystic ovarian syndrome).

  • Loss of sexual desire.

  • Obesity which restricts fertility.

  • Vaginal and cervical dryness.

How to Use This Cream?

A person may start applying this cream after the ovulation process. If the patient uses the cream by mistake before the ovulation period, it will give an opposite effect. It restricts the fertility process rather than enhancing fertility. The ovulation process is restricted when the person starts to apply the Progesterone cream before ovulation. As the hormone progesterone is a stimulator of menstruation, it may lead to miscarriage. A high level of progesterone in the body is responsible for the initiation of menstruation. So, if it is used early, it is used to induce menstruation rather than improve fertility.

Transdermal application over the skin is very beneficial. It is a fat-soluble protein. When it is applied over the skin, it is absorbed by the fat tissues beneath the skin. It is stored in the fat tissues, and then it releases the hormone into the pelvic blood vessels. From the blood vessels, it is pumped to the heart, and from the heart, it goes to different parts of the body.

What Is the Dosage?

A woman may apply this cream on the abdomen, face, inner thigh, upper neck, chest, breast, palms, and feet. But for better function, the inner thigh or lower abdomen is preferred as it directly reaches the target tissue.

If it is used in premenopausal women, 16 to 25 mg per day is very beneficial when applied 14 days before the menstruation date. It should be stopped on the day of menstruation or before periods.

It is most effective when it is applied over the inner thigh from the twelfth day of the cycle to the twenty-sixth day. It increases the formation of endometrial tissues within the uterus. It helps to make the uterus ready for the implanted fertilized egg.

Menopausal women can also use this for conceiving. Research shows that Progesterone cream will act as a stimulus for menses. They can take 15 mg, and it is to be taken for the first 25 days of the month, then take five or six days off and restart on the first of the month.

Some research shows that if women divide the dose and apply it two times a day, it would be more beneficial than applying the whole dose once a day. So, there are many beneficial effects of the Progesterone cream for fertility. It is a non-surgical and cheap method for conceiving.

Loading Dose:

This method is useful for those who have a severe deficiency of progesterone hormone. The deficiency of progesterone causes a lack of ovulation. This woman becomes estrogen-dominant due to the reduction of progesterone stores in the body. This type of woman is usually thin and has little fat tissues in her body. In such a woman, a higher dose will be recommended, approximately 40 mg, two times per day to start ovulation for two months. After that, the dose will be decreased to the standard dose.

What Is the Complication of This Cream?

Do not apply too much over the target area, or it will cause hormonal imbalance in the body. The effect of the cream starts within a few seconds of application. When the woman begins to apply a hormonal cream, its effects last for a few hours after use. But later on, problems may start. Splitting the dosage may decrease this problem. Splitting it two times a day is a better option than applying the entire dose all at once.

Topical application of Progesterone has negligible adverse effects on the body. The cream also contains the perfect amount which does not harm bodily functions. Gel and cream both are available and equally effective.

A Word of Caution:

When the person is applying this cream over the skin, the skin will absorb the cream as well as the hormone in the fat tissue. Fat tissue stores this hormone. Initially, the cream provides beneficial effects because the storage of the hormone is very low, but as time goes on, peak saturation of fat tissue may be achieved. Progesterone is a highly fat-soluble hormone. After many applications, the fat tissue will become saturated with the hormone, and it does not provide any beneficial effects.

Sometimes, over-saturation may produce harmful effects. This condition is referred to as dermal fatigue. After reaching the saturation point, progesterone may hamper the adrenal hormone, cortisol, and testosterone. That is why progesterone cream is to be used with caution.

Frequently Asked Questions


Where Is Progestrogene Cream Applied for Fertility?

The progesterone cream can be applied to the chest, neck, breast, inner thighs, inner arms, and belly. It is recommended to change the area of application if any irritation occurs. It helps women dealing with fertility issues.


Can Progesterone Cream Make the Person Fertile?

Research has shown that the use of progesterone helps in increasing the fertility levels of women and reduces the chances of miscarriage. It is usually made up of soybeans. Progesterone cream helps to prepare the uterus for pregnancy.


What Days Should the Person Use Progesterone Cream?

The cream should be applied after the ovulation during the menstrual cycle, which is almost around day 14 of the menstrual cycle (however, the ovulation day may vary depending upon the length of the menstrual cycle). The cream can be applied to the forearm, lower abdomen, neck, or inner thighs. The cream application can be continued until 28 days after the periods begin.


How Can Women Increase Fertility Fast?

Fertility can be increased by consuming antioxidant-rich food, such as food containing zinc and folate. Avoidance of trans fat is good for health as well as for fertility of a woman. A high-fat diet can boost energy and enhance the fertility of the woman.


Is It Safe to Use Progesterone if Trying to Conceive?

Progesterone is essentially used to increase fertility and is used in infertility treatments. It supports pregnancy and implantation mechanisms in women. Studies and surveys suggest that progesterone supplementation supports pregnancy and helps in preventing early miscarriage.


How Fast Is the Working of Progesterone Cream?

The working of progesterone depends upon the individual and their symptoms. The results can be seen in the very first cycle and even after two-three months of application. It depends upon the woman's body and how the progesterone cream reacts.


When Progesterone Can Be Taken to Get Pregnant?

Progesterone should be taken one to three days after ovulation. According to the research, progesterone supplementation taken during the luteal phase just after ovulation increases the chances of pregnancy. Progesterone pills are also used to increase women's fertility during infertility treatment.


Can Progesterone Cream Be Used During Period?

Progesterone cream can be used at night twice daily for two weeks before the period starts. The use of progesterone cream should be stopped as the period begins. A small amount of progesterone can be used in case of cramps or pain during the menstrual cycle.


How Safe Is Progesterone Cream?

Progesterone creams are very effective in increasing the fertility of women. Natural progesterone, when used during fertility treatment, has no threat to the child and mother. It can be consumed by women with a history of multiple miscarriages.


Can Progesterone Cream Make a Woman's Period Start?

The progesterone cream cannot make the women's period start early. It should be stopped if the periods begin early. Progesterone pills instead of cream can be used to regulate the menstrual cycle, and the period is expected to start three to seven days after taking the progesterone pills.


Why is Progesterone Taken at Night?

Progesterone is taken before going to bed since it has certain sedative effects. It helps regulate the menstrual cycle and has more sedative effects during the night. It is a biomedical hormone and not a drug.


Can Progesterone Cream Lead To Weight Gain?

In some cases, progesterone cream can lead to moderate weight gain. Long-term progesterone cream is as effective as progesterone pills. Progesterone gives dominance to estrogen, which helps to store more fat, leading to weight gain.


Can Progesterone Lead To Bigger Breast Size?

Breasts tend to grow in response to estrogen and progesterone hormone. Progesterone stimulates the development and growth of milk-producing cells. Therefore progesterone leads to bigger breast size in females.


What Happens When a Person Consumes Too Much Progesterone?

High consumption of progesterone leads to agitation, breast swelling, tenderness, depression, anxiety, weight gain, and fatigue. Progesterone in excessive amounts can often cause heart stroke, dementia, or blood clot. The risk of heart disease after progesterone consumption increases if the person is a chronic smoker.


How to Know When Progesterone Is Required?

Progesterone is required when the progesterone level is low, which causes short cycles and irregular periods. Progesterone is a type of hormone replacement therapy that helps to reduce menopause symptoms. Progesterone cream is made up of wild yams and soybeans.
Source Article IclonSourcesSource Article Arrow
Talati Vidhi Hareshbhai
Talati Vidhi Hareshbhai



Community Banner Mobile
By subscribing, I agree to iCliniq's Terms & Privacy Policy.

Source Article ArrowMost popular articles

Do you have a question on


Ask a Wellness Expert online

*guaranteed answer within 4 hours

Disclaimer: Wellness medicine is not aimed to replace the services of your treating physician or allopathy medicines. Our site's information is to those who are willing to take responsibility for their health, being fully aware that the content published herein would not qualify as a prescription or specific medical advice. If users use the information and stop prescribed medication without their physician's consent, they bear full responsibility for their actions, and iCliniq-Wellness bears no responsibility for the same. Information on Wellness medicine should not be misinterpreted as a cure for any illness, as our body is complex and everyone reacts differently.

This website uses cookies to ensure you get the best experience on our website. iCliniq privacy policy