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Q. Are there chances of drug interactions in taking MK-677 along with Fluphenazine and SDZ-Quetiapine?

Answered by
Dr. Arul Amuthan
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on Jun 20, 2022

Hello doctor,

I am currently taking the tablet Fluphenazine and SDZ-Quetiapine XR. I was wondering if I could take the tablet MK-677 (Ibutamoren). How long do I have to wait before taking it after my first two medications? I would like to know about drug interactions.

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Hello,

Welcome to icliniq.com.

Quetiapine stays in the blood for six to seven hours, whereas Fluphenazine stays in the blood for at least 12 to 16 hours, but it varies from person to person. If one consumes Fluphenazine tablet within six hours of Quetiapine tablet consumption, it will have some additive effect or drug interaction. Even though Qutiapine interacts with many other drugs that are metabolized by cytochrome P450 enzymes, it does not interact with Fluphenazine. In your case, if you are taking sustained-release tablet Quetiapine XR, it will not reach a high level in blood within six hours. Instead, it will be reaching blood in less quantity for a longer period. Hence, it might stay in the blood for more than seven hours. A lower concentration of Quetiapine in the blood is safe because it does not interact with the second drug. So, the benefits of each drug will add up. Also, the side effects of individual tablets will be added up. As such, there is no drug interaction between the two. If you wish to maintain the gap between the two drugs, consume Fluphenazine at night and Quetiapine XR in the morning. If this can control your symptoms satisfactorily, it is fine. If not, we need to give both together or increase the frequency of Quetiapine XR.

Thank you doctor for the reply,

I understood those two medications are fine together, but my question was if tablets Quetiapine XR and Fluphenazine can also be taken with MK-677 (Ibutamoren). If so, how long do I have to wait to take this? I currently take tablets Quetiapine XR and Fluphenazine at night. I also want to also add the tablet MK-677 (Ibutamoren) but I am not sure how far apart I should take it from those two tablets.

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Hello,

Welcome back to icliniq.com.

The tablet MK-677 (Ibutamoren) is a growth hormone secretagogue, so it is better to take it early morning. During that time, there are a number of hormonal feedback mechanisms that are active and help balance the hormones. So, if you take the tablet at this time, there will not be any hormonal disturbances.

Thank you doctor for the reply,

Can I also take Melatonin tablets along with tablets MK-677, Quetiapine XR, and Fluphenazine? If so, how far apart should I take these drugs from other medications?

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Hello,

Welcome back to icliniq.com.

Melatonin tablets should be taken 30 minutes before bedtime because the drug starts showing its effect in 30 minutes. So, it should be taken 30 minutes before the actual sleep time at night. Do not take during the day any other time, because you will not get much benefit. It can be safely taken with other drugs.

Thank you doctor for the reply,

I am happy to know that there will not be any problem if I take the drugs simultaneously.

#

Hello,

Welcome back to icliniq.com.

Melatonin is naturally released in our bodies at night. So, melatonin should always be taken at night. If you take it during the daytime, it will further collapse the endogenous melatonin secretions.

Thank you doctor for the reply,

I am satisfied with the information you provided regarding drug interactions.

#

Hello,

Welcome back to icliniq.com.

I am happy to help you and you can consult me for further queries.

Thank you doctor for the reply,

I would like to know if I can take multivitamin capsules with the medications I am taking. If so, when should I take it?

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Hello,

Welcome back to icliniq.com.

You can take multivitamin capsules with those drugs without any issues. Generally, B-complex (vitamin B) capsules are fine. If you have nerve tremor or weakness, I suggest you take the capsule Neurobion Forte (multivitamins).

Thank you doctor for the reply,

How about taking Creatine Monohydrate and protein powder with my medications, and when should I take it?

#

Hello,

Welcome back to icliniq.com.

No research was done on the interactions between Creatine Monohydrate or protein powder and the drugs you are taking. So, I assume there will not be any interactions. In general, I suggest you keep a gap of 30 to 60 minutes between the above supplements and those drugs.

Thank you doctor for the reply,

I saw this online, but is it true that one should wait for three to four hours before taking any other medication?

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Hello,

Welcome back to icliniq.com.

Each drug has its own half-life and depending on that, we need to fix the time of the second drug. If both drugs are not interacting with each other, they can be taken together. It takes 30 minutes to three hours for a drug to get absorbed from the intestine into the blood.


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