Q. Is it safe to have Ashwagandha along with Effexor and Trazodone?

Answered by
Dr. Arul Amuthan L
and medically reviewed by Dr.Nithila A
This is a premium question & answer published on May 11, 2019

Hello doctor,

I am on Effexor 187 mg and Trazodone 50 mg at night for depression and anxiety. My depression and anxiety have been worse, and I did not want to keep going up on with more medicines. So I tried Ashwagandha 600 mg in the morning and have seen a great deal of help in my mood and anxiety. I have not even considered if it is safe with my medication. Kindly advice.



Welcome to

Effexor (Venlafaxine) and Trazodone are good drugs for depression and anxiety but will have some side effects. You may take Ashwagandha 600 mg (morning and night), Centella Asiatica (morning and night) as a supportive therapy. There must be one hour gap between modern drugs and herbal supplements, to prevent their interactions. Consuming Ashwagandha and Centella Asiatica is safe. On a long term basis, it will reduce the side effects of modern tablets and also stabilize the nervous system functions.

Thank you doctor,

I had Er-positive and Pr-positive breast cancer and I am on a hormone blocker. My oncologist said I can use Ashwaganda, but I am just concerned if it produces estrogen or progesterone? I have not been able to find very much information on it. Kindly advice.



Welcome back to

There are enough researches done on the chemopreventive (and anticancer) effect of Ashwagandha on estrogen and progesterone receptors positive tumors. All the preclinical data showed the supportive result that Ashwagandha itself has anticancer and prevents cell multiplication in these supportive hormone tumors.

Only countable number of clinical researches have been done on this plant in breast cancer. Ashwagandha can help in restoring energy level after cancer therapy. However, in your case, you may clinically or through a lab, continuously monitor the outcome in cancer benefit. I feel this herb will be beneficial to you.

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